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2. Loop diuretic - Wikipedia

   en.wikipedia.org/wiki/Loop_diuretic

   Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis. [10]

3. Diuretic - Wikipedia

   en.wikipedia.org/wiki/Diuretic

   The term "low-ceiling diuretic" is used to indicate a diuretic has a rapidly flattening dose effect curve (in contrast to "high-ceiling", where the relationship is close to linear). Certain classes of diuretic are in this category, such as the thiazides .

4. Ceiling effect (pharmacology) - Wikipedia

   en.wikipedia.org/wiki/Ceiling_effect_(pharmacology)

   In pharmacology, the term ceiling effect refers to the property of increasing doses of a given medication to have progressively smaller incremental effect (an example of diminishing returns). Mixed agonist-antagonist opioids , such as nalbuphine , serve as a classic example of the ceiling effect; increasing the dose of a narcotic frequently ...

5. Low-threshold spikes - Wikipedia

   en.wikipedia.org/wiki/Low-threshold_spikes

   Low-threshold calcium spikes have been described in neurons from a variety of brain nuclei, including the thalamic relay, medial pontine reticular formation, lateral habenula, septum, deep cerebellar nuclei, CA1-CA3 of the hippocampus, association cortex, paraventricular and preoptic nuclei of the hypothalamus, dorsal raphe, globus pallidus ...

6. Low-threshold treatment program - Wikipedia

   en.wikipedia.org/wiki/Low-threshold_treatment...

   Low-threshold treatment programs are harm reduction-based health care centers targeted towards people who use substances. [1] " Low-threshold" programs are programs that make minimal demands on the patient, offering services without attempting to control their intake of drugs, and providing counselling only if requested.

7. AOL Mail

   mail.aol.com

   Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!

8. Subthreshold membrane potential oscillations - Wikipedia

   en.wikipedia.org/wiki/Subthreshold_membrane...

   These findings illustrate that there are high frequencies of SMPO in dorsal cells and low frequencies in the ventral cells. [ 13 ] [ 19 ] A similar study that did whole-cell recordings of olivary neurons in vivo to investigate the relationship between subthreshold activities and spiking behavior in an intact brain illustrates that the majority ...

9. Group C nerve fiber - Wikipedia

   en.wikipedia.org/wiki/Group_C_nerve_fiber

   includes CT fibres, also known as C low-threshold mechanoreceptors (CLTM), which are unmyelinated afferents found in human hairy skin, and have a low mechanical threshold < 5 milliNewtons. They have moderate adaptation and may exhibit fatigue on repetitive stimulation and "afterdischarges" for several seconds after a stimulus.