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  2. Osteoporosis - Wikipedia

    en.wikipedia.org/wiki/Osteoporosis

    The process takes place in bone multicellular units (BMUs) as first described by Frost & Thomas in 1963. [101] Osteoclasts are assisted by transcription factor PU.1 to degrade the bone matrix, while osteoblasts rebuild the bone matrix. Low bone mass density can then occur when osteoclasts are degrading the bone matrix faster than the ...

  3. Matrix (biology) - Wikipedia

    en.wikipedia.org/wiki/Matrix_(biology)

    In biology, matrix (pl.: matrices) is the material (or tissue) in between a eukaryotic organism's cells. The structure of connective tissues is an extracellular matrix. Fingernails and toenails grow from matrices. It is found in various connective tissues. It serves as a jelly-like structure instead of cytoplasm in connective tissue.

  4. Bone resorption - Wikipedia

    en.wikipedia.org/wiki/Bone_resorption

    Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.

  5. Osteoblast - Wikipedia

    en.wikipedia.org/wiki/Osteoblast

    The functional part of bone, the bone matrix, is entirely extracellular. The bone matrix consists of protein and mineral. The protein forms the organic matrix. It is synthesized and then the mineral is added. The vast majority of the organic matrix is collagen, which provides tensile strength. The matrix is mineralized by deposition of ...

  6. Demineralized bone matrix - Wikipedia

    en.wikipedia.org/wiki/Demineralized_bone_matrix

    Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix. It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins . [ 1 ]

  7. Osteolysis - Wikipedia

    en.wikipedia.org/wiki/Osteolysis

    Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification.Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process.

  8. Osteoclast - Wikipedia

    en.wikipedia.org/wiki/Osteoclast

    An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue.This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton.

  9. Osteon - Wikipedia

    en.wikipedia.org/wiki/Osteon

    The Haversian canal contains the bone's blood supplies. The boundary of an osteon is the cement line. Each Haversian canal is surrounded by varying number (5-20) of concentrically arranged lamellae of bone matrix. Near the surface of the compact bone, the lamellae are arranged parallel to the surface; these are called circumferential lamellae.