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A bone scan or bone scintigraphy / s ɪ n ˈ t ɪ ɡ r ə f i / is a nuclear medicine imaging technique used to help diagnose and assess different bone diseases. These include cancer of the bone or metastasis, location of bone inflammation and fractures (that may not be visible in traditional X-ray images), and bone infection (osteomyelitis). [1]
A renogram, which may also be known as a MAG3 scan, allows a nuclear medicine physician or a radiologist to visualize the kidneys and learn more about how they are functioning. [1] MAG3 is an acronym for mercapto acetyl tri glycine , a compound that is chelated with a radioactive element – technetium-99m .
The technetium-99m radioisotope is used predominantly in bone and brain scans. For bone scans , the pertechnetate ion is used directly, as it is taken up by osteoblasts attempting to heal a skeletal injury, or (in some cases) as a reaction of these cells to a tumor (either primary or metastatic) in the bone.
Effective doses can range from 6 μSv (0.006 mSv) for a 3 MBq chromium-51 EDTA measurement of glomerular filtration rate to 11.2 mSv (11,200 μSv) for an 80 MBq thallium-201 myocardial imaging procedure. The common bone scan with 600 MBq of technetium-99m MDP has an effective dose of approximately 2.9 mSv (2,900 μSv). [24]
In the same way that a plain X-ray is a 2-dimensional (2-D) view of a 3-dimensional structure, the image obtained by a gamma camera is a 2-D view of 3-D distribution of a radionuclide. SPECT imaging is performed by using a gamma camera to acquire multiple 2-D images (also called projections ), from multiple angles.
The most common isotope used in diagnostic scans is Technetium-99m, used in approximately 85% of all nuclear medicine diagnostic scans worldwide. It is used for diagnoses involving a large range of body parts and diseases such as cancers and neurological problems. [ 1 ]
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Technetium (99m Tc) tetrofosmin is a drug used in nuclear medicine cardiac imaging. It is sold under the brand name Myoview ( GE Healthcare ). The radioisotope , technetium-99m , is chelated by two 1,2- bis [di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin .