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Fluorouracil. Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer. [3]
FOLFIRINOX is a chemotherapy regimen for treatment of advanced pancreatic cancer. It is made up of the following four drugs: FOL – folinic acid (leucovorin), a vitamin B derivative that enhances the effects of 5-fluorouracil (5-FU); [1][2] F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates into the DNA ...
FOLFIRI. FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer. It is made up of the following drugs: [1] FOL – folinic acid (leucovorin), a vitamin B derivative with multiple applications, which in this context decreases the cytotoxicity of 5-fluorouracil; F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which ...
Research has revealed that neural progenitor cells are particularly vulnerable to the cytotoxic effects of chemotherapy agents. 5-fluorouracil has been demonstrated to reduce the viability of neural progenitor cells by 55–70% at concentrations of 1 μM, whereas cancer cell lines exposed to 1 μM of 5-fluorouracil were unaffected. [24]
FOLFOX is given directly into the bloodstream through an intravenous line. It can be given through a thin, short tube (a cannula) put into a vein in the arm each time one has a treatment. It may also be given through a central line, a portacath, or a PICC line. These are long, plastic tubes that give the drugs directly into a large vein in the ...
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Antimetabolites masquerade as pyrimidine -like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle.
FOLFOXIRI is a chemotherapy regimen for the treatment of advanced colorectal cancer. [1][2][3][4][5] The role of FOLFOXIRI in colorectal cancer has been reviewed. [1][6] The chemotherapy regimen is made up of the following four drugs: FOL – folinic acid (leucovorin), a vitamin B derivative that modulates/potentiates/reduces the side effects ...
Common side effects include bone marrow suppression, loss of appetite, diarrhea, vomiting, and psychosis. [2] Anaphylaxis and other allergic reactions occasionally occur. [2] It is unclear if use in pregnancy is safe for the baby. [4] Flucytosine is in the fluorinated pyrimidine analogue family of medications. [2]
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