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[2] [4] Plants do not need cobalamin and carry out the reactions with enzymes that are not dependent on it. [5] Vitamin B 12 is the most chemically complex of all vitamins, [6] and for humans the only vitamin that must be sourced from animal-derived foods or supplements. [2] [7] Only some archaea and bacteria can synthesize vitamin B 12. [8]
6% (< 60 years old), 20% (> 60 years old) [4] Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [5] Symptoms can vary from none to severe. [1] Mild deficiency may have few or absent symptoms. [1]
Technically, B12 doesn’t increase metabolism per se. But B12 could affect your metabolism, as one study suggests that a deficiency could be linked to increased fat accumulation and obesity. Does ...
Serum vitamin B12. Serum vitamin B12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
If your doctor suspects you may have a B12 deficiency, they can do a lab test to check B12 levels in your blood: A normal serum B12 level is between 300 pg/mL and 900 pg/mL.
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Frequency. 1 per 1000 people [8] Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of vitamin B 12. [5] Those affected often have a gradual onset. [5] The most common initial symptoms are feeling tired and weak. [4]
Vitamin B. 12. total synthesis. The total synthesis of the complex biomolecule vitamin B 12 was accomplished in two different approaches by the collaborating research groups of Robert Burns Woodward at Harvard [1][2][3][4][5] and Albert Eschenmoser at ETH [6][7][8][9][10][11][12] in 1972. The accomplishment required the effort of no less than ...
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