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Deaths. 59,800 (2015) [ 6 ] Melanoma is the most dangerous type of skin cancer; it develops from the melanin -producing cells known as melanocytes. [ 1 ] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [ 1 ][ 2 ] In women, melanomas most commonly occur on the legs; while in men, on the ...
Superficial spreading melanoma (SSM) is a type of skin cancer that typically starts as an irregularly edged dark spot typically on sun-exposed part of the body. [2][3] The colour may be variable with dark, light and reddish shades; occasionally no color at all. [2] It typically grows in diameter before spreading to deeper tissue, forming a bump ...
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; [1] the term is typically used when referring to metastasis by a cancerous tumor. [2] The newly pathological sites, then, are metastases (mets). [3][4] It is generally distinguished from cancer invasion, which is ...
Acral lentiginous melanoma is the most common subtype in people with darker skins and is rare in people with lighter skin types. [7] It is not caused by exposure to sunlight or UV radiation, and wearing sunscreen does not protect against it. Acral lentiginous melanoma is commonly found on the palms, soles, under the nails, and in the oral ...
Because there are no lymphatic channels to the uveal tract, metastasis occurs through local extension and/or blood-borne dissemination. [20] The most common site of metastasis for uveal melanoma is the liver; [21] the liver is the first site of metastasis for 80%-90% of ocular melanoma patients. [22]
A malignant tumor is defined by its capacity to initiate a biological phenomenon known as the metastatic cascade, a complex multi-stage process in which cell invasion precedes further cancer progression and the formation of metastases in distant organs and tissues. Massive metastatic lesions lead to the development of organ failure.
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