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Deaths. 59,800 (2015) [ 6 ] Melanoma is the most dangerous type of skin cancer; it develops from the melanin -producing cells known as melanocytes. [ 1 ] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [ 1 ][ 2 ] In women, melanomas most commonly occur on the legs; while in men, on the ...
The most common site of metastasis for uveal melanoma is the liver; [21] the liver is the first site of metastasis for 80%-90% of ocular melanoma patients. [22] Other common sites of metastasis include the lung, bones, and just beneath the skin (subcutaneous).
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; [1] the term is typically used when referring to metastasis by a cancerous tumor. [2] The newly pathological sites, then, are metastases (mets). [3][4] It is generally distinguished from cancer invasion, which is ...
Superficial spreading melanoma (SSM) is a type of skin cancer that typically starts as an irregularly edged dark spot typically on sun-exposed part of the body. [2][3] The colour may be variable with dark, light and reddish shades; occasionally no color at all. [2] It typically grows in diameter before spreading to deeper tissue, forming a bump ...
B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for the study of metastasis and solid tumor formation, and were one of the first effective murine tools for metastasis research. These cells readily metastasize to lymph nodes and lungs.
This gene is found in 30- 89% of melanoma cases (Dahl et al., 2007), and causes cells to grow quickly. This fast growth is important in the quick metastasis of melanoma cells, and when hypermethylated, the growth and spread of cells slow considerably (Hoeller et al., 2005). This is a controversial finding with inconclusive results, though.
1.8 million (2020) [3] Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic damage to the DNA of cells in the airways, often caused by cigarette smoking or inhaling damaging chemicals. Damaged airway cells gain the ability to multiply unchecked, causing the growth of a tumor.
Squamous-cell carcinoma. Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. [1] These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts.
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