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Aztreonam is similar in action to penicillin. It inhibits synthesis of the bacterial cell wall, by blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-binding protein -3 and mild affinity for penicillin-binding protein-1a.
A frequent clinical question is whether these patients can safely receive the structurally related cephalosporins or carbapenems (monobactams [ie, aztreonam] are not cross-reactive with penicillins and can be safely given to penicillin-allergic patients).
The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis.
It is a synthetic bactericidal antibiotic. The monobactams, having a unique monocyclic beta-lactam nucleus, are structurally different from other beta-lactam antibiotics (eg, penicillins,...
No, aztreonam (Azactam) isn't a penicillin; it's a monobactam antibiotic. Although aztreonam (Azactam) and penicillins are similar to each other because they are both types of antibiotics called beta-lactams, aztreonam (Azactam) can be given to people with a severe penicillin allergy. But to be safe, make sure to tell your provider if you have ...
carbapenems, cephalosporins, and penicillins. Aztreonam is commonly used to treat people who are allergic to some beta-lactam antibiotics and is used in combination with other antibiotics to treat certain antibiotic-resistant bacteria.
Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams. Aztreonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria.
Although studies suggest that aztreonam is rarely cross-reactive, prescribe and administer aztreonam with caution in patients who have had a history of hypersensitive reactions to other beta-lactam antibiotics including penicillins, cephalosporins or carbapenems.
Aztreonam is a monobactam antibiotic that contains a betalactam ring. However, unlike other beta-lactam antibiotics, aztreonam does not contain a bicyclic-ring structure ( 6 ). To date, aztreonam has not demonstrated clinical cross-reactivity in penicillin-allergic patients ( 2 , 8 ).
Introduction. Antibacterial; monocyclic β-lactam antibiotic; monobactam. Uses for Aztreonam. Intra-abdominal Infections.