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This review focuses on clinical practice guidelines for transfusion of three blood components: RBCs, platelets and plasma. In addition, we provide the approach used to implement clinical practice guidelines at our own institution.
Transfusion of blood products is one of the most common medical procedures, used for patients with a wide range of medical conditions to improve tissue oxygenation, achieve hemostasis, and/or fight infections.
Minimizing unnecessary complications of transfusion and responding to the ongoing global challenges of having a safe and secure blood supply will require effective strategies, including blood management programs, for implementation of these guidelines.
Appropriate uses of red blood cell (RBC) transfusion. Treatment of symptomatic anemia. Prophylaxis in life-threatening anemia. Restoration of oxygen-carrying capacity in case of hemorrhage. RBCs are also indicated for exchange transfusion. Sickle cell disease.
Red Blood Cell Transfusion: 2023 AABB International Guidelines. Updated guidelines, published in JAMA and developed by an international panel of experts led by AABB, recommended a restrictive red blood cell transfusion strategy for most patient populations, but emphasized the importance of considering individual signs & symptoms and clinical ...
When considering transfusion of any blood product, it is good practice to consider the patient's relevant laboratory data, overall clinical circumstances, feasible alternatives, and adjuncts to...
Currently, guidelines for the transfusion of red blood cells (RBC) generally follow a restrictive threshold. While there is some variation in the number for the threshold, 7 g/dL is an agreed-upon value for asymptomatic healthy patients.
Recommendation 1: for hospitalized adult patients who are hemodynamically stable, the international panel recommends a restrictive transfusion strategy considering transfusion when the hemoglobin concentration is less than 7 g/dL (strong recommendation, moderate certainty evidence).
This guideline covers the assessment for and management of blood transfusions in adults, young people and children over 1 year old. It covers the general principles of blood transfusion, but does not make recommendations relating to specific conditions.
Updated guidelines in the form of blood transfusion strategy recommendations are available. The blood transfusion recommendations have been published and are titled “The Red Blood Cell (RBC) 2023 Transfusion Association for the Advancement of Blood & Biotherapies (AABB) International Guidelines.”