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Modeling is responsible for the circumferential growth of bone and expansion of marrow cavity Remodeling is a continuous process, in which damaged bone is repaired, ion homeostasis is maintained, and bone is reinforced for increased stress; entire remodeling cycle requires ~ 6 months
Histology demonstrates multiple cornoid lamellae involving a mildly hyperplastic epidermis. Answer A is incorrect because Bowen disease is a form of in situ squamous cell carcinoma. Although Bowen disease may present similarly to porokeratosis, it is rare in patients younger than 30 years of age (Indian Dermatol Online J 2022;13:177).
Trabecula, sheets or cords of neoplastic cells with abundant oncocytic cytoplasm cells in background of dense collagen bundles frequently arranged in parallel lamellae Cells are large and polygonal with well defined cell borders Abundant granular and eosinophilic cytoplasm due to abundant mitochondria
Circumferential resection margin (CRM) or nonperitonealized margin involvement strongly predicts local recurrence and is found to be associated with poor survival (J Clin Oncol 2008;26:303, Ann Surg 2002;235:449)
Steady increase in incidence each year in developed countries since the 1970s through 2000, with the incidence rate eventually stabilizing in the United States through 2017 (J Natl Cancer Inst 2008;100:1184, Gastrointest Endosc Clin N Am 2021;31:1)
Circumferential trophoblastic hyperplasia Cytologic atypia of intermediate trophoblasts at the implantation site Smooth villous contours but surface invaginations with trophoblastic pseudoinclusions may also occur Absence of fetal vessels and fetal red blood cells Complete hydatidiform mole (early): No significant villous enlargement or hydrops
12 year old girl with breast mass (Int J Surg Case Rep 2017;41:427) 16 year old girl with 28 cm left breast mass (BMJ Case Rep 2019;12:e227277)
Stroma: also called substantia propria, no blood vessels or lymphatics, 90% of cornea's thickness, contains regularly spaced collagen fibrils; normally separated by glycoprotein and mucoprotein which makes cornea transparent; normally see stromal lamellae separated by clefts, a processing artifact, absence of clefts is caused by stroma edema ...
No annulate lamellae in Sertoli cells; microcrystal formation but no Reinke crystals in Leydig cells (Arch Pathol Lab Med 1982;106:228) Male pseudohermaphroditism Definition / general
The placenta is a fetomaternal organ that provides gas exchange, nourishment and protection to the fetus, while the umbilical cord is the anatomic tubular structure that physically connects the developing intrauterine fetus to the placenta