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Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
The NADPH pathway (both 6PGD and G6PD reactions) is the only source of reductant to reduce glutathione in red blood cells. The role of erythrocytes as oxygen carriers puts them at risk of being damaged by oxidizing free radicals. The reduction of glutathione acts as an antioxidant and prevents damage from reactive oxygen species. [citation needed]
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Various genetic studies on Filipinos have been performed, to analyze the population genetics of the various ethnic groups in the Philippines.. The results of a DNA study conducted by the National Geographic's "The Genographic Project", based on genetic testings of Filipino people by the National Geographic in 2008–2009, found that the Philippines is made up of around 53% Southeast Asia and ...
This category includes articles on the History of the Philippines (1986–present), Contemporary Era. Subcategories This category has the following 3 subcategories, out of 3 total.
The ATC has tagged multiple local based groups in the Philippines in 2020 who have pledged allegiance to the militant Islamist group Islamic State based in Iraq and Syria using multiple United Nations Security Council resolutions to justify the designation including Resolution Nos. 1373 and 2253. One noted incident was the Marawi siege of 2017. [5]
The history of the Philippines dates from the earliest hominin activity in the archipelago at least by 709,000 years ago. [1] Homo luzonensis, a species of archaic humans, was present on the island of Luzon [2] [3] at least by 134,000 years ago. [4] The earliest known anatomically modern human was from Tabon Caves in Palawan dating about 47,000 ...