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Terbinafine is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot. [1][2][3] It is either taken by mouth or applied to the skin as a cream or ointment. [1][4] The cream and ointment should not be used for fungal nail infections. [5]
Caspofungin (INN; [1] [4] brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc.. [5] It is a member of a class of antifungals termed the echinocandins. [medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. [5] It is also used to prevent candidiasis in those who are at high risk such as following organ transplantation, low birth ...
In late 2022, the WHO published its first-ever list of fungal priority pathogens — 19 fungi the agency said pose a significant threat to human health. It includes the highly drug-resistant yeast ...
Other serious side effects include low blood potassium and myocarditis (inflammation of the heart). [3] It appears to be relatively safe in pregnancy. [4] There is a lipid formulation that has a lower risk of side effects. [4] It is in the polyene class of medications and works in part by interfering with the cell membrane of the fungus. [3] [4]
Itraconazole. Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. [7] This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. [7] It may be given by mouth or intravenously.
The side effects of ketoconazole are sometimes harnessed in the treatment of non-fungal conditions. While ketoconazole blocks the synthesis of the sterol ergosterol in fungi, in humans, at high dosages (>800 mg/day), it potently inhibits the activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as ...