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Normal adult: 0.2 [84] 0.5 [84] ng/dL 3.1 [86] 7.7 [86] ... 0.4 [144] 3.1 [144] x10 9 /L ... Anti-mitochondrial antibodies (AMA) < 0.1 [168] 0.1-0.9 [168]
This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. [ 14 ] The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical).
The loops, or three-dimensional structures of the non-H3 CDRs (all CDRs but H3) of antibodies have been clustered and classified by Chothia et al. [6] and more recently by North et al. [7] Homology modeling is a computational method to build tertiary structures from amino-acid sequences. The so-called H3-rules are empirical rules to build ...
Phytosterols are widely recognized as having a proven LDL cholesterol lowering efficacy' [61] A 2018 review found a dose-response relationship for phytosterols, with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%, [62] but reviews as of 2017 had found no data indicating that the consumption of phytosterols may reduce the risk of CVD. [63]
A panel-reactive antibody (PRA) is a group of antibodies in a test serum that are reactive against any of several known specific antigens in a panel of test leukocytes or purified HLA antigens from cells. It is an immunologic metric routinely performed by clinical laboratories on the blood of people awaiting organ transplantation. [1]
Anti-transglutaminase antibodies (ATA) are autoantibodies against the transglutaminase protein. Detection is considered abnormal, and may indicate one of several conditions . Antibodies serve an important role in the immune system by detecting cells and substances that the rest of the immune system then eliminates.
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The framework regions are highly conserved regions of the variable portion of the antibody. The evolutionary reason for the conservation of these regions is to support proper folding of the antibody allowing the CDR regions to be stabilized. Folding in FR leads to antibody structure flexibility or rigidity of the binding region of the antibody ...
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