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Deuremidevir, also known as VV116, is a nucleoside analogue antiviral drug. It is administrated through oral tablets, which contain the hydrobromide salt of this drug. [1]The drug is a deuterated tri-isobutyrate of GS-441524, the active metabolite of remdesivir.
Fosdesdenosine sipalabenamide is an investigational new drug that is being evaluated for the treatment of advanced solid tumors and lymphoma. [1] This compound is a phosphoramidate derivative of cordycepin (3'-deoxyadenosine), an adenosine analog originally isolated from the fungus Cordyceps.
entry inhibitor: Methisazone: Smallpox: Molnupiravir: COVID-19: Merck & Co. viral RNA polymerase inhibitor Moroxydine: Influenza Nelfinavir: HIV Nirmatrelvir/ritonavir (Paxlovid) COVID-19: Pfizer: 3C-like protease inhibitor (Nirmatrelvir) / inhibition of metabolism of nirmatrelvir (ritonavir) Nevirapine: HIV non-nucleoside reverse transcriptase ...
Ribonuclease inhibitor (RI) is a large (~450 residues, ~49 kDa), acidic (pI ~4.7), leucine-rich repeat protein that forms extremely tight complexes with certain ribonucleases. It is a major cellular protein, comprising ~0.1% of all cellular protein by weight, and appears to play an important role in regulating the lifetime of RNA .
Image illustrates DNA, RNA, and protein synthesis. The first two are nucleic acids. A nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA inhibitors. [1] The antifungal flucytosine acts in a similar manner.
As a nucleoside inhibitor, the guanosine analog prodrug is used to stop viral RNA synthesis and viral mRNA capping by incorporating into RNA and pairing to uracil or cytosine. Branaplam is currently in phase I/II clinical trial for the treatment of Spinal Muscular Atrophy (SMA). This molecule is from a class of pyridazine small molecules and ...
GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences.It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients.
Transcription of mRNAs initiated by viral polymerase using cap snatching. The first step of transcription for some negative, single-stranded RNA viruses is cap snatching, in which the first 10 to 20 residues of a host cell RNA are removed (snatched) and used as the 5′ cap and primer to initiate the synthesis of the nascent viral mRNA. [1]
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