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Phenoxymethylpenicillin was first made in 1948 by Eli Lilly. [5]: 121 It is on the World Health Organization's List of Essential Medicines. [6] It is available as a generic medication. [4] In 2022, it was the 259th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [7] [8]
In the 1940s, a vial of 5,000 Oxford units was standard, [24] but the depending on the batch, could contain anything from 15 mg to 20 mg of penicillin. Later, a vial of 1,000,000 international units became standard, and this could contain 2.5 g to 3 g of natural penicillin (a mixture of penicillin I, II, III, and IV and natural impurities).
The usual dose by mouth is one capsule of 250 mg 4 times a day in adults and half the adult dose as a syrup for children under the age of 10 years but over 2. [4] For children below the age of 2 years, the oral dose is a quarter of the adult oral dose. [3] Ampicillin/flucloxacillin is taken orally about half an hour before food. [5]
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PPI (standard dose) bid, rifabutin 0.15 g bid and amoxicillin 1 g bid Third line therapy Furazolidone-based quadruple therapy 10-14 PPI (standard dose) bid, bismuth standard dose qid, tetracycline 0.5 g bid and furazolidone 200 mg bid First line for penicillin-allergic patients Note: qd – once daily, bid – twice daily, qid – four times a day
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The side effects of penicillin are bodily responses to penicillin and closely related antibiotics that do not relate directly to its effect on bacteria. A side effect is an effect that is not intended with normal dosing. [1]
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