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Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. [2] Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion .
Extreme couponing is an activity that combines shopping skills with couponing in an attempt to save as much money as possible while accumulating the most groceries. The concept of "extreme couponers" was first mentioned by The Wall Street Journal on March 8, 2010, in an article entitled "Hard Times Turn Coupon Clipping Into the Newest Extreme Sport". [2]
Believed to be the first coupon ever, this ticket for a free glass of Coca-Cola was first distributed in 1888 to help promote the drink. By 1913, the company had redeemed 8.5 million tickets. [6] Coca-Cola's 1888-issued "free glass of" is the earliest documented coupon. [6] [7] Coupons were mailed to potential customers and placed in magazines ...
However, a free trial in exchange for credit card details can not be stated as a free trial, as there is a component of expenditure. While forced free trials can be an effective marketing technique, there are ethical concerns when companies require customers to provide credit card information for a supposedly "free" trial.
To change this template's initial visibility, the |state= parameter may be used: {{Extreme Makeover: Home Edition | state = collapsed}} will show the template collapsed, i.e. hidden apart from its title bar. {{Extreme Makeover: Home Edition | state = expanded}} will show the template expanded, i.e. fully visible.
Brentuximab vedotin [6] consists of the chimeric monoclonal antibody brentuximab (cAC10, which targets the cell-membrane protein CD30) linked with maleimide attachment groups, cathepsin-cleavable linkers (valine-citrulline), and para-aminobenzylcarbamate spacers to three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected by the 'vedotin' in the drug's name). [7]
An alternative statement is: given n coupons, how many coupons do you expect you need to draw with replacement before having drawn each coupon at least once? The mathematical analysis of the problem reveals that the expected number of trials needed grows as Θ ( n log ( n ) ) {\displaystyle \Theta (n\log(n))} .
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