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Therefore, effects include an overall decrease in bone recycling/turnover as well as an increased inhibition of the absorptive bone abilities [clarification needed]. Light micrograph of an osteoclast displaying typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy" cytosol.
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.
Osteonecrosis can affect any bone, but the hips, knees and jaws are most often involved. Pain can often be severe, especially if teeth and/or a branch of the trigeminal nerve is involved, but many patients do not experience pain, at least in the earlier stages.
Side chain that is made out of three carbons has proven to be the most ideal length in terms of activity, increasing or decreasing the length of the chain from there has negative effect on biological activity. Alendronate, a common bisphosphonate drug, has a three carbon length side chain for example. [17]
Alendronic acid/colecalciferol, sold under the brand name Fosamax Plus D among others, is a medication for the treatment of osteoporosis in men or in postmenopausal women. [ 3 ] [ 2 ] [ 4 ] [ 6 ] Alendronic acid/colecalciferol was approved for use in the United States and in the European Union in 2005.
If you have more sensitive teeth, err on the side of less time. For best results, try not to eat or drink for 15 minutes afterward to give the ingredients time to continue working.
Teeth that are tender to percussion, which may develop as the condition progresses. Loosening of teeth, which may develop as the condition progresses. Pus may later be visible, which exudes from around the necks of teeth, from an open socket, or from other sites within the mouth or on the skin over the involved bone. Fetid odor.
For those with osteoporosis but who have not had a fracture, evidence does not support a reduction in fracture risk with risedronate [6] or etidronate. [11] Alendronate decreases fractures of the spine but does not have any effect on other types of fractures. [5] Half stop their medications within a year. [174]