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The fine speckled pattern has fine nuclear staining with unstained metaphase chromatin, which is associated with anti-Ro and anti-La antibodies. The coarse staining pattern has coarse granular nuclear staining, caused by anti-U1-RNP and anti-Sm antibodies. The nucleolar staining pattern is associated with many antibodies including anti-Scl-70 ...
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
High-dose estrogen therapy with diethylstilbestrol for endometriosis was first reported by Karnaky in 1948 and was the main pharmacological treatment for the condition in the early 1950s. [ 190 ] [ 191 ] [ 192 ] Pseudopregnancy (high-dose estrogen–progestogen therapy) for endometriosis was first described by Kistner in the late 1950s.
HEp-2 cells provide a greater ability to differentiate patterns of ANA than animal sections, due to the large nuclei and high mitotic rate of the cell line. Upon incubation with serum containing anti-dsDNA antibodies and fluorescent labelled secondary antibodies, homogeneous staining of interphase nuclei and condensed chromosomal staining of ...
Endometriosis is estimated to occur in 7% to 10% of women, with an associated risk of infertility for between 30% and 50% of this population. [1] [2] [3] Endometriosis is commonly classified under the revised American Society for Reproductive Medicine system from minimal endometriosis to severe endometriosis. The therapy and management of ...
The ANA tests for the presence or absence of autoantibodies, while the ENA panel evaluates which proteins in the cell nucleus the autoantibodies recognize. The ENA panel helps diagnosis, distinguish between, and monitor the progression of autoimmune diseases and is performed with a simple blood draw.
Speckle patterns have been used in a variety of applications in microscopy, [20] [21] imaging, [22] [23] and optical manipulation. [24] [25] [26] When lasers were first invented, the speckle effect was considered to be a severe drawback in using lasers to illuminate objects, particularly in holographic imaging because of the grainy image produced.
Endometrioma is found in 17–44% patients with endometriosis. [2] More broadly, endometriosis is the presence of tissue similar to, but distinct from, endometrial tissue located outside the uterus. The presence of endometriosis can result in the formation of scar tissue, adhesions and an inflammatory reaction.