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One significant cell-line cross contaminant is the immortal HeLa cell line. HeLa contamination was first noted in the early 1960s in non-human culture in the USA. Intraspecies contamination was discovered in nineteen cell lines in the seventies. In 1974, five human cell lines from the Soviet Union were found to be HeLa.
There are several examples of immortalised cell lines, each with different properties. Most immortalised cell lines are classified by the cell type they originated from or are most similar to biologically 3T3 cells – a mouse fibroblast cell line derived from a spontaneous mutation in cultured mouse embryo tissue.
Gordon Hisashi Sato (17 December 1927 – 31 March 2017) was an American cell biologist who first attained prominence for his discovery that polypeptide factors required for the culture of mammalian cells outside the body are also important regulators of differentiated cell functions and of utility in culture of new types of cells for use in research and biotechnology.
In 1998, Thomson's Lab was the first to report the successful isolation of human embryonic stem cells. On November 6, 1998, Science published this research in an article titled "Embryonic Stem Cell Lines Derived from Human Blastocysts", results which Science later featured in its “Scientific Breakthrough of the Year” article, 1999. [3]
C2C12 is an immortalized mouse myoblast cell line. The C2C12 cell line is a subclone of myoblasts that were originally obtained by Yaffe and Saxel at the Weizmann Institute of Science in Israel in 1977. [1] Developed for in vitro studies of myoblasts isolated from the complex interactions of in vivo conditions, C2C12 cells are useful in ...
Sir Martin John Evans FRS FMedSci FLSW (born 1 January 1941) is an English biologist [5] who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981.
The degree of HeLa cell contamination among other cell types is unknown, because few researchers test the identity or purity of already established cell lines. It has been shown that a substantial fraction of in vitro cell lines are contaminated with HeLa cells; estimates range from 10% to 20%.
Horizon now offers over 23,000 cell line pairs that model the mutations found in genetically based diseases. These ‘patients-in-a-test-tube’ are may be used to identify the effect of individual or compound genetic mutations on drug activity, patient responsiveness, and resistance, which may lead to prediction of which patient sub-groups ...
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