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The T cells recognize myelin as foreign and attack it, explaining why these cells are also called "autoreactive lymphocytes". Demyelination, further inflammation and axonal transection are the result. The attack of myelin starts inflammatory processes, which triggers other immune cells and the release of soluble factors like cytokines and ...
Depending on the extent of injury, the cellular response may be adaptive and where possible, homeostasis is restored. [1] Cell death occurs when the severity of the injury exceeds the cell's ability to repair itself. [2] Cell death is relative to both the length of exposure to a harmful stimulus and the severity of the damage caused. [1]
Myelin was first described in 1854 by Rudolf Virchow, [17] although it was over a century later, following the development of electron microscopy, that its glial cell origin and its ultrastructure became apparent. [18] In vertebrates, not all axons are myelinated. For example, in the PNS, a large proportion of axons are unmyelinated.
Cell bodies of neurons are in yellow (Their axons are surrounded by myelin, produced by oligodendrocytes). Cellular extensions also known as cytoplasmic protrusions and cytoplasmic processes are those structures that project from different cells , in the body, or in other organisms.
Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, are a heterogenous group of demyelinating diseases - conditions that cause damage to myelin, the protective sheath of nerve fibers - that occur against the background of an acute or chronic inflammatory process.
The most accepted hypothesis is that dialogue between T-cell receptors and myelin antigens leads to an immune attack on the myelin-oligodendrocyte complex. These interactions between active T cells and myelin antigens provoke a massive destructive inflammatory response and promote continuing proliferation of T and B cells and macrophage ...
Myelin clearance is the next step in Wallerian degeneration following axonal degeneration. The cleaning up of myelin debris is different for PNS and CNS. PNS is much faster and efficient at clearing myelin debris in comparison to CNS, and Schwann cells are the primary cause of this difference.
The T cells recognize myelin as foreign and attack it, explaining why these cells are also called "autoreactive lymphocytes". [ 1 ] The attack on myelin starts inflammatory processes, which trigger other immune cells and the release of soluble factors like cytokines and antibodies .