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Klinefelter syndrome (KS), also known as 47,XXY, is a chromosome anomaly where a male has an extra X chromosome. [10] These complications commonly include infertility ...
Klinefelter’s syndrome occurs when a man is born with one or more extra X chromosomes, leading to a variety of impacts that include underdeveloped testicles, impaired testosterone production ...
48,XXYY syndrome is a condition related to the X and Y chromosomes (the sex chromosomes). People normally have 46 chromosomes in each cell.Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics.
Klinefelter syndrome is the most common sex chromosome aneuploidy in humans. It represents the most frequent cause of hypogonadism and infertility in men. Most cases are caused by nondisjunction errors in paternal meiosis I. [ 2 ] About eighty percent of individuals with this syndrome have one extra X chromosome resulting in the karyotype XXY.
Like Klinefelter syndrome, the presence of additional X chromosomes affects the male reproductive system, can cause physical abnormalities, and can affect cognitive development. When comparing 47,XXY and 48,XXXY, there is a greater risk for congenital malformations and more medical problems in those with 48,XXXY.
Klinefelter is a German surname, which is a variant of Kleinfelder. [1] This is a topographic name for a person who worked a smallholding , or a toponymic surname for a person from one of the places called Kleinfeld in Germany . [ 2 ]
Harry Fitch Klinefelter Jr. (/ ˈ k l aɪ n f ɛ l t ər /; March 20, 1912 – February 20, 1990) was an American rheumatologist and endocrinologist. Klinefelter syndrome is named after him. Biography
Klinefelter syndrome, the most common male chromosomal disease, otherwise known as 47,XXY, is caused by an extra X chromosome. Edwards syndrome is caused by trisomy (three copies) of chromosome 18. Down syndrome, a common chromosomal disease, is caused by trisomy of chromosome 21. Patau syndrome is caused by trisomy of chromosome 13.