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Lamotrigine has not demonstrated clear efficacy in treating acute mood episodes, either mania or depression. It has not demonstrated effectiveness in treating acute mania, [27] and there is controversy regarding the drug's effectiveness in treating acute bipolar depression. [28] A paper written in 2008 by Nassir et al. reviewed evidence from ...
Lamotrigine is considered a first-line agent for the treatment of bipolar depression. It is effective in preventing the recurrence of both mania and depression, but it has not proved useful in treating acute mania. [2] Zonisamide (trade name Zonegran), another anti-convulsant, also may show promise in treating bipolar depression. [18]
Lamotrigine (aka Lamictal) – FDA approved for bipolar disorder maintenance therapy, not for acute mood problems like depression or mania/hypomania. [7] The usual target dose is 100–200 mg daily, titrated to by 25 mg increments every 2 weeks. [8] Lamotrigine can cause Stevens–Johnson syndrome, a very rare but potentially fatal skin ...
Symptoms of Bipolar Disorder. The single most telling symptom of bipolar disorder is the episodic oscillation between high and low mood states — characteristic shifts between depression, normal ...
It is more effective in BP-II than BP-I, suggesting that lamotrigine is more effective for the treatment of depressive rather than manic episodes. Doses ranging from 100 to 200 mg have been reported to have the most efficacy, while experimental doses of 400 mg have rendered little response. [39]
According to the study, bipolar is estimated to cost the UK economy about £20 billion a year and represents 17% of the total burden of mental illness, while depression represents 23%.