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Conglomerate masses can also develop in sarcoidosis, [5] but usually near the hilae and with surrounding paracicatricial emphysema. The disease arises firstly through the deposition of silica or coal dust (or other dust) within the lung, and then through the body's immunological reactions to the dust.
The most common mediastinal masses are thymoma (20% of mediastinal tumors), usually found in the anterior mediastinum, followed by neurogenic Timor (15–20%) located in the anterior mediastinum. [1] Lung cancer typically spreads to the lymph nodes in the mediastinum.
Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic damage to the DNA of cells in the airways, often caused by cigarette smoking or inhaling damaging chemicals. Damaged airway cells gain the ability to multiply unchecked, causing the growth of a tumor.
A lung cavity or pulmonary cavity is an abnormal, thick-walled, air-filled space within the lung. [1] Cavities in the lung can be caused by infections, cancer, autoimmune conditions, trauma, congenital defects, [2] or pulmonary embolism. [3] The most common cause of a single lung cavity is lung cancer. [4]
In recent years, various molecular targeted therapies have been developed for the treatment of advanced lung cancer. Gefitinib (Iressa; withdrawn from the U.S. market) is one such drug, which targets the tyrosine kinase domain of the epidermal growth factor receptor (EGFR), expressed in many cases of non-small cell lung carcinoma.
Figure A shows the location of the lungs and airways in the body. The inset image shows a detailed view of the lung's airways and air sacs in cross-section. Figure B shows fibrosis (scarring) in the lungs. The inset image shows a detailed view of the fibrosis and how it damages the airways and air sacs. [1] Specialty: Pulmonology: Symptoms
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