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Armodafinil exhibits linear time-independent kinetics following single and multiple oral dose administration. Increase in systemic exposure is proportional over the dose range of 50–400 mg. No time-dependent change in kinetics was observed through 12 weeks of dosing. Apparent steady state for armodafinil was reached within 7 days of dosing.
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
A dosage of up to 200–250 mg daily for a sustained period of six to twelve months may be needed to cure hyperacusis. A possible mechanism of action of this drug is that clomipramine reduces reactions of the autonomic nervous system to sounds. [53] The drug ambroxol helps relieve the pain experienced by several pain hyperacusis patients.
Modafinil is a drug that helps keep people awake and alert (wakefulness-promoting agent or "eugeroic"). [ 1 ] [ 2 ] Most of the listed modafinil analogues are drugs that specifically target dopamine reuptake (reabsorption of a neurotransmitter by a neurotransmitter transporter ) with stronger effects ( selective DRIs with improved potency ...
Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness, [6] vertigo, [8] Ménière's disease, [9] or Cogan's syndrome. [3] It is one of only a few drugs that has a beneficial effect in the chronic treatment of the vertigo and tinnitus associated with Ménière's disease.
For the first time in two decades, the Food and Drug Administration (FDA) has approved a new class of medication that provides an alternative to addictive opioids for patients looking to manage ...
Of the more than twenty compounds preclinically tested in Cephalon's three-part drug discovery series, the compound fluorenol was selected as a lead. [26] Fluorenol was found to induce wakefulness to a greater degree than modafinil, despite possessing a lower affinity for the dopamine transporter (DAT). [ 26 ]
Neuromonics is a non-invasive sound therapy used to manage tinnitus. The therapy involves a customized acoustic stimulus delivered through headphones for a prescribed amount of time each day. It is typically used as part of a comprehensive tinnitus management program that includes counselling, education, and support.