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Paroxysmal attacks in various disorders have been reported extensively, and ephaptic coupling of demyelinated nerves has been presumed as one of the underlying mechanisms of this phenomenon. This is supported by the presence of these attacks in multiple sclerosis and tabes dorsalis, which both involve demyelination of spinal cord neurons.
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
Paroxysmal exercise-induced dyskinesia DYT19 611031: probably PRRT2: 16q13-q22.1 Episodic kinesigenic dyskinesia 2, probably synonymous with DYT10 DYT20 611147: unknown 2q31 Paroxysmal nonkinesigenic dyskinesia 2 DYT21 614588: unknown 2q14.3-q21.3 Late-onset torsion dystonia DYT24 610110: ANO3 [11] 11p14.2
Benign paroxysmal positional vertigo is more likely in someone who gets repeated episodes of vertigo with movement and is otherwise normal between these episodes. [9] Benign vertigo episodes generally last less than one minute. [2] The Dix-Hallpike test typically produces a period of rapid eye movements known as nystagmus in this condition. [1]
Orthopnea or orthopnoea [1] is shortness of breath (dyspnea) that occurs when lying flat, [2] causing the person to have to sleep propped up in bed or sitting in a chair. It is commonly seen as a late manifestation of heart failure, resulting from fluid redistribution into the central circulation, causing an increase in pulmonary capillary pressure and causing difficulty in breathing.
Nasal itching and paroxysmal sneezing are usually associated with nonallergic rhinitis rather than allergic rhinitis. [4] [5] Other symptoms that are more specific to non-allergic rhinitis include ear plugging or discomfort with eustachian tube dysfunction, headaches, sinus pressure, and muffled hearing. Common triggers for non-allergic ...
Platypnea or platypnoea is shortness of breath (dyspnea) that is relieved when lying down, and worsens when sitting or standing upright. It is the opposite of orthopnea. [1] The condition was first described in 1949 and named in 1969.
Hysteria is a term used to mean ungovernable emotional excess and can refer to a temporary state of mind or emotion. [1] In the nineteenth century, female hysteria was considered a diagnosable physical illness in women.