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Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]
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Consider the sunburn, a deterministic effect: [4] when exposed to bright sunlight for only ten minutes [5] at a high UV Index, that is to say a high average dose rate, [6] the skin can turn red and painful. The same total amount of energy from indirect sunlight spread out over several years - a low average dose rate - would not cause a sunburn ...
Boxer cardiomyopathy (also known as "Boxer arrhythmogenic right ventricular cardiomyopathy") is a disease of the myocardium primarily affecting Boxer dogs.It is characterized by the development of ventricular tachyarrhythmias, resulting in syncope and sudden cardiac death.
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Pulmonary drug delivery is a route of administration in which patients use an inhaler to inhale their medications and drugs are absorbed into the bloodstream via the lung mucous membrane. This technique is most commonly used in the treatment of lung diseases, for example, asthma and chronic obstructive pulmonary disease (COPD) .
A photoplethysmogram (PPG) is an optically obtained plethysmogram that can be used to detect blood volume changes in the microvascular bed of tissue. [1] [2] A PPG is often obtained by using a pulse oximeter which illuminates the skin and measures changes in light absorption. [3]
So, the maintenance dose of foosporin is 100 milligrams (100 mg) per day—just enough to offset the amount cleared. Suppose a patient just started taking 100 mg of foosporin every day. On the first day, they'd have 100 mg in their system; their body would clear 10 mg, leaving 90 mg.