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Acetophenone is formed as a byproduct of the cumene process, the industrial route for the synthesis of phenol and acetone.In the Hock rearrangement of isopropylbenzene hydroperoxide, migration of a methyl group rather than the phenyl group gives acetophenone and methanol as a result of an alternate rearrangement of the intermediate:
tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me 3 C)Me 2 SiCl (Me = CH 3).It is commonly abbreviated as TBSCl or TBDMSCl. It is a chlorosilane containing two methyl groups and a tert-butyl group.
A typical reaction involving two ketones is that between acetophenone as the enol and acetone: [7] Mukaiyama aldol between two ketones. Ketone reactions of this type require higher reaction temperatures. For this work Mukaiyama was inspired by earlier work done by Georg Wittig in 1966 on crossed aldol reactions with lithiated imines.
Tris-buffered saline (TBS) is a buffer used in some biochemical techniques to maintain the pH within a relatively narrow range. Tris (with HCl) has a slightly alkaline buffering capacity in the 7–9.2 range. The conjugate acid of Tris has a pK a of 8.07 at 25 °C. The pK a declines approximately 0.03 units per degree Celsius rise in ...
Phenacyl chloride, also commonly known as chloroacetophenone, is a substituted acetophenone.It is a useful building block in organic chemistry.Apart from that, it has been historically used as a riot control agent, where it is designated CN. [5]
[14] [10] These reagents activate the acyl chloride via a nucleophilic catalysis mechanism. The amine attacks the carbonyl bond and presumably [23] first forms a transient tetrahedral intermediate, then forms a quaternary acylammonium salt by the displacement of the leaving group. This quaternary acylammonium salt is more susceptible to ...
In the laboratory, this compound may be prepared by treating sodium cyanide with acetone, followed by acidification: [3]. Considering the high toxicity of acetone cyanohydrin, a lab scale production has been developed using a microreactor-scale flow chemistry [4] to avoid needing to manufacture and store large quantities of the reagent.
Pyrylium salts are easily produced from simple starting materials through a condensation reaction. [2]Pyrylium salts with aromatic substituents, such 2,4,6-triphenylpyrylium tetrafluoroborate, can be obtained from two moles of acetophenone, one mole of benzaldehyde, and excess tetrafluoroboric acid. [3]