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In the absence of albinism or hyperpigmentation, the human epidermis contains approximately 74% eumelanin and 26% pheomelanin, largely irrespective of skin tone, with eumelanin content ranging between 71.8–78.9%, and pheomelanin varying between 21.1–28.2%. [7]
Eumelanin is found in hair, areola, and skin, and the hair colors gray, black, blond, and brown. In humans, it is more abundant in people with dark skin. Pheomelanin, a pink to red hue is found in particularly large quantities in red hair, [16] the lips, nipples, glans of the penis, and vagina. [17]
There are also differences in the quantity and relative amounts of eumelanin and pheomelanin. [13] Pigmentation including tanning is under hormonal control, including the MSH and ACTH peptides that are produced from the precursor proopiomelanocortin. Vitiligo is a skin disease where people lack melanin in certain areas in the skin.
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Cross-sectional view showing skin tone becoming darker due to the production of more melanin to overcome DNA damage caused by UV radiation. Melanin is a natural pigment produced by cells called melanocytes in a process called melanogenesis. [6] Melanocytes produce two types of melanin: pheomelanin (red) and eumelanin (very dark brown). Melanin ...
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