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However, a study in the Mirena application for FDA approval found a lower continuation of breastfeeding at 75 days in hormonal IUD users (44%) versus copper IUD users (79%). [39]: 37 When using Mirena, about 0.1% of the maternal dose of levonorgestrel can be transferred via milk to the nursed infant. [40]
It works by preventing fertilization or implantation but does not affect already implanted embryos. [37] It contains no hormones, so it can be used while breastfeeding, and fertility returns quickly after removal. [39] Copper IUDs also last longer and are available in a wider range of sizes and shapes than hormonal IUDs. [14]
The original (six capsule) Norplant was approved by the U.S. Food and Drug Administration (FDA) on December 10, 1990, and marketed in the United States in 1991 by Wyeth Pharmaceuticals. [20] Norplant distribution in the United States ended in 2002; limited supplies still remained in the U.S. until 2004.
In an intrauterine device (IUD), such as Mirena among others, it is effective for the long-term prevention of pregnancy. [11] A levonorgestrel-releasing implant is also available in some countries. [16] Common side effects include nausea, breast tenderness, headaches, and increased, decreased, or irregular menstrual bleeding. [11]
For example, a failure rate of 20% means that 20 of 100 women become pregnant during the first year of use. Note that the rate may go above 100% if all women, on average, become pregnant within less than a year. In the degenerated case of all women becoming pregnant instantly, the rate would be infinite.
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