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The bullae are formed by an immune reaction, initiated by the formation of IgG [citation needed] autoantibodies targeting dystonin, also called bullous pemphigoid antigen 1, [6] and/or type XVII collagen, also called bullous pemphigoid antigen 2, [7] which is a component of hemidesmosomes. A different form of dystonin is associated with ...
Pemphigus foliaceus skin eruption on the abdomen of a dog. Pemphigus foliaceus has been recognized in pet dogs, cats, and horses, and is the most common autoimmune skin disease diagnosed in veterinary medicine. PF in animals produces clusters of small vesicles that quickly evolve into pustules. Pustules may rupture, forming erosions or become ...
Bullous pemphigoid is most commonly seen in Dobermanns and Collies and appears as a scald-like lesion of the groin. [83] Sebaceous adenitis is an uncommon autoimmune skin disease. Most commonly found in Akitas and Standard Poodles. [84]
Other autoimmune diseases include bullous pemphigoid and epidermolysis bullosa acquisita. Treatment of autoimmune skin diseases in dogs requires methods to reduce the abnormal immune response; steroids, azathioprine and other drugs are used as immunosuppressive agents.
Bites and stings as well as other conditions (e.g. drug reactions, urticarial reactions, and early bullous pemphigoid) can cause microscopic changes such as a wedge-shaped superficial dermal perivascular infiltrate consisting of abundant lymphocytes and scattered eosinophils, as shown in the adjacent figure: [12]
Pemphigoid is a group of rare autoimmune blistering diseases of the skin and mucous membranes.As its name indicates, pemphigoid is similar in general appearance to pemphigus, [1] however unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.
Mucous membrane pemphigoid is a rare chronic autoimmune subepithelial blistering disease characterized by erosive lesions of the mucous membranes and skin. [3] It is one of the pemphigoid diseases that can result in scarring.
Pemphigoid nodularis is a cutaneous condition that is a variant of bullous pemphigoid that has skin lesions mimicking prurigo nodularis. [ 1 ] The antibody involved is IgG .
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