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The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C
Printable version; Page information; ... Will update with all enzyme names once diagram is checked for accuracy. ... The androgen backdoor pathway (red arrows ...
removed 11KT since it is not a significant product of the 11-oxy backdoor pathway: 17:21, 18 February 2024: 1,200 × 675 (365 KB) Boghog: Reverted to version as of 11:25, 17 February 2024 (UTC) 14:08, 18 February 2024: 1,200 × 675 (371 KB) Boghog: Added the 11-oxy backdoor pathway is also important in healthy females: 11:25, 17 February 2024: ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone. [ 7 ] [ 8 ] [ 9 ] 5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen , i.e., it binds to the progesterone receptors .
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone [27] [28] [29] CAH is a genetic disorder characterized by impaired production of cortisol in the adrenal glands. [1] [4] Production of cortisol begins at week 8 of fetal ...
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5α-Reductase (1, 2, 3) – androgen and neurosteroid synthesis, progestogen metabolism; 5β-Reductase – androgen and progestogen metabolism, neurosteroid synthesis; Conjugation (and deconjugation) Glucuronosyltransferase – steroid metabolism [6] Glucuronidase (β-glucuronidase) – steroid synthesis [7]
These findings indicate that CYP17A1 plays a role in the metabolism of this steroid through both hydroxylation and lyase reactions in the 11-oxygenated steroid backdoor pathway to androgens. [ 1 ] [ 6 ] This pathway is important for regulating adrenal and gonadal steroid hormone biosynthesis and can contribute to elevated levels of androgens in ...