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The idea of a link between parasite infection and immune disorders was first suggested in 1968 [13] before the advent of large scale DNA sequencing techniques.The original formulation of the hygiene hypothesis dates from 1989, when David Strachan proposed that lower incidence of infection in early childhood could be an explanation for the rise in allergic diseases such as asthma and hay fever ...
The Hygiene hypothesis postulates that decreasing exposure to pathogens and other microorganisms results in an increase of autoimmune diseases, according to Rook. [17] This theory and the theory that certain parasitic worms pacify the immune response are similar in that both theories attribute the recent rise of autoimmune diseases to the ...
Since the germ theory of disease, cleanliness has come to mean an effort to remove germs and other hazardous materials.A reaction to an excessive desire for a germ-free environment began around 1989, when David Strachan put forth the "hygiene hypothesis" in the British Medical Journal.
The hygiene hypothesis states that infants and children who lack exposure to infectious agents are more susceptible to allergic diseases via modulation of immune system development. The theory was first proposed by David P. Strachan who noted that hay fever and eczema were less common in children who belonged to large families. [62]
Recent research has linked the emerging idea of the hygiene hypothesis to viruses. This hypothesis attempts to explain some of the high incidences of diseases such as asthma [ 24 ] and eczema [ 25 ] in the Western world by Western societies' overuse of antibiotic and antiviral agents.
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This therapy ties to the Hygiene hypothesis in that the lack of exposure to bacteria and parasites such as helminths can cause a weaker immune system leading to being more susceptible to autoimmune disease. [4] [5] Helminth worms are members of two phyla: nematodes, which are primarily used in human helminthic therapy, and flat worms . [2]
A test method is a method for a test in science or engineering, such as a physical test, chemical test, or statistical test. It is a definitive procedure that produces a test result. [ 1 ] In order to ensure accurate and relevant test results, a test method should be "explicit, unambiguous, and experimentally feasible.", [ 2 ] as well as ...