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  2. Hydralazine - Wikipedia

    en.wikipedia.org/wiki/Hydralazine

    Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. [2] This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms . [ 3 ]

  3. Oral administration - Wikipedia

    en.wikipedia.org/wiki/Oral_administration

    Oral administration can be easier and less painful than other routes of administration, such as injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may ...

  4. Onset of action - Wikipedia

    en.wikipedia.org/wiki/Onset_of_action

    Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration , it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question.

  5. Antihypertensive - Wikipedia

    en.wikipedia.org/wiki/Antihypertensive

    [42] [43] Hydralazine and its derivatives are also used in the treatment of severe hypertension, although they should be avoided in emergencies. [43] They are no longer indicated as first-line therapy for high blood pressure due to side effects and safety concerns, but hydralazine remains a drug of choice in gestational hypertension. [42]

  6. Hydrazinophthalazine - Wikipedia

    en.wikipedia.org/wiki/Hydrazinophthalazine

    This pharmacological action results in decreased peripheral resistance and lowered blood pressure. While hydralazine is the most well-known compound in this class, other related drugs such as dihydralazine also belong to the hydrazinophthalazine family and exhibit similar antihypertensive properties. These compounds have been in clinical use ...

  7. Route of administration - Wikipedia

    en.wikipedia.org/wiki/Route_of_administration

    Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).

  8. Hydralazine/isosorbide dinitrate - Wikipedia

    en.wikipedia.org/wiki/Hydralazine/isosorbide...

    It is a combination of hydralazine hydrochloride (an arteriolar vasodilator) and isosorbide dinitrate (a nitrate vasodilator). [ 1 ] [ 2 ] The US Food and Drug Administration (FDA) approved medication to treat congestive heart failure in specifically self-identified Black patients.

  9. Tachyphylaxis - Wikipedia

    en.wikipedia.org/wiki/Tachyphylaxis

    Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). [1] It can occur after an initial dose or after a series of small doses.

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