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Oxazolidine is a five-membered heterocycle ringwith the formula (CH 2) 3 (NH)O.The O atom and NH groups are not mutually bonded, in contrast to isoxazolidine. [2] [3] Oxazolidines (emphasis on plural) are derivatives of the parent oxazolidine owing to the presence of substituents on carbon and/or nitrogen. Oxazolines are unsaturated analogues ...
An additional global Phase 3 study is planned for acute bacterial skin and skin structure infections (ABSSSI) for the combination of contezolid and contezolid acefosamil. An oxazolidinone derivative used for other purposes is rivaroxaban , which is approved by the U.S. FDA for venous thromboembolism prophylaxis.
This is a list of aminorex analogues. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, [1] [2] [3] but withdrawn from sale after it was discovered that extended use produced pulmonary hypertension, often followed by heart failure, which resulted in a number of deaths. [4]
Trimethadione (Tridione) is an oxazolidinedione anticonvulsant.It is most commonly used to treat epileptic conditions that are resistant to other treatments.. It is primarily effective in treating absence seizures, but can also be used in refractory temporal lobe epilepsy.
The oxazolidones and isoxazolidones are a set of six isomeric five-membered heterocyclic compounds consisting of a carbonyl group, an oxygen atom, a nitrogen atom with a hydrogen atom attached, and two methylene groups.
Isoxazolidines can be produced by the nitrone-olefin (3+2) cycloaddition reaction. They represent precursors to 1,3-aminoalcohols. [2] The series Organic Syntheses provides detailed procedures that yield isoxazolidines, e.g., from styrene [3] and N-phenylmaleimide. [4] Some isoxazolidines are of medicinal interest. [5]
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Stiripentol, sold under the brand name Diacomit, is an anticonvulsant medication used for the treatment of Dravet syndrome - a serious genetic brain disorder. [5] [6]The most common side effects include loss of appetite, weight loss, insomnia (difficulty sleeping), drowsiness, ataxia (inability to co‑ordinate muscle movements), hypotonia (low muscle strength) and dystonia (muscle disorders).