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Perilipin 4, also known as S3-12, is a protein that in humans is encoded by the PLIN4 gene on chromosome 19. [5] [6] It is highly expressed in white adipose tissue, with lower expression in heart, skeletal muscle, and brown adipose tissue. [7] PLIN4 coats lipid droplets in adipocytes to protect them from lipases.
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
4. Stress. Stress can lead to overeating, eating high-calorie or high-fat foods, and sleep loss. When you’re stressed, the stress hormone cortisol reduces your brain’s sensitivity to leptin ...
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
Obesity BMI. The National Heart, Lung, and Blood Institute defines obesity as a body mass index (BMI) of 30 or more. BMI is a measurement of body fat based on a person’s height and weight. An ...
The second category is pre-clinical obesity, which is obesity with normal organ function, but acknowledges the increased risk of developing clinical obesity and other diseases, such as including ...
16p11.2 deletion syndrome is a rare genetic condition caused by microdeletion on the short arm of chromosome 16. Most affected individuals experience global developmental delay and intellectual disability, as well as childhood-onset obesity. [1] 16p11.2 deletion is estimated to account for approximately 1% of autism spectrum disorder cases. [3] [4]
Unilateral injuries on just one side typically don’t have a major impact if the unaffected testicle is healthy. Cancer treatments. Chemotherapy and radiation therapy can cause permanent problems ...