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Withdrawal symptoms can be seen after long-term use of normal doses even after a gradual reduction regimen. The Compendium of Pharmaceuticals and Specialties recommends zopiclone prescriptions not exceed 7 to 10 days, owing to concerns of addiction, tolerance, and physical dependence. [ 78 ]
In addition, the effectiveness and safety of long-term use of these agents remain to be determined. It was concluded that more research is needed to evaluate the long-term effects of treatment and the most appropriate management strategy for elderly persons with chronic insomnia. [18] A 2009 meta-analysis found a higher rate of infections. [19]
Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [10] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999. [3]
Long-term use is not recommended as tolerance and addiction can occur. [17] Zolpidem and zaleplon are, in the US, indicated for 7-10 days of use only. Longer periods of use lead to loss of efficacy from tolerance. [18] Tolerance has also been demonstrated with zopiclone, [19] which is indicated for a maximum of 4 weeks of use in New Zealand. [20]
Elavil (amitriptyline) – a tricyclic antidepressant used as a first-line treatment for neuropathic pain; Eurodin, Prosom – a benzodiazepine derivative with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, commonly prescribed for short-term treatment of insomnia
Benzodiazepine withdrawal syndrome (BZD withdrawal) is the cluster of signs and symptoms that may emerge when a person who has been taking benzodiazepines as prescribed develops a physical dependence on them and then reduces the dose or stops taking them without a safe taper schedule.
In fact, long-term use of Ozempic may reduce the risk of major adverse cardiovascular events like heart attack in people with type 2 diabetes. stefanamer / iStock 6.
Long-term use and benzodiazepine dependence is a serious problem in the elderly. Failure to treat benzodiazepine dependence in the elderly can cause serious medical complications. [ 14 ] The elderly have less cognitive reserve and are more sensitive to the short (e.g., in between dose withdrawal) and protracted withdrawal effects of ...