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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
The essential spliceosome component U2AF bound to a short polypyrimidine RNA fragment. The polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying out RNA splicing during the process of post-transcriptional modification.
The phosphorylation of specific tyrosine residues within the activated receptor creates binding sites for Src homology 2 (SH2) domain- and phosphotyrosine binding (PTB) domain-containing proteins. [ 10 ] [ 11 ] Specific proteins containing these domains include Src and phospholipase C γ.
They include protein K and polypyrimidine tract-binding protein (PTB), which is regulated by phosphorylation catalyzed by protein kinase A and is responsible for suppressing RNA splicing at a particular exon by blocking access of the spliceosome to the polypyrimidine tract.
Beyoncé has donated a large sum to support the communities tragically affected by the ongoing wildfires in Los Angeles.. On Sunday, Jan. 12, the singer’s BeyGOOD foundation announced via ...
First son Hunter Biden's "sugar brother" and lawyer Kevin Morris won't be disbarred for infiltrating a film project about President Biden's role in his family's foreign dealings, The Post has learned.
In molecular biology, phosphotransferases are proteins in the transferase family of enzymes (EC number 2.7) that catalyze certain chemical reactions. The general form of the phosphorylation reactions they catalyze is: