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Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine. [4] The latter causes the alpha 2- adrenergic agonist effects. [5] It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid that can be administered as an intravenous drug solution with sterile water.
“This is the way drugs travel.” The rise of medetomidine comes as overdose deaths have fallen slightly. More than 107,000 people died of a drug overdose last year, down from about 111,000 in ...
Medetomidine, a powerful animal tranquilizer, has emerged as one of the latest substances found mixed with other common street drugs. The drug has recently been cited as the likely culprit behind ...
“Medetomidine’s presence in the illicit drug supply is an emerging public health issue across the nation,” said Michelle Haese, state Department of Health Services director of substance use ...
[1] [2] It contains medetomidine, an alpha2-adrenoceptor agonist, as the hydrochloride; and vatinoxan, an alpha2-adrenoceptor antagonist, as the hydrochloride. [ 2 ] [ 3 ] It was approved for veterinary use in the United States in May 2022, [ 2 ] and in Canada in May 2023.
Dexmedetomidine was developed by Orion Pharma and is marketed under the names dexdor® and Precedex®; in 1999 the US Food and Drug Administration (FDA) approved it as a short-term sedative and analgesic (<24 hours) for critically ill or injured people on mechanical ventilation in the intensive care unit. The rationale for its short-term use ...
Atipamezole is a veterinary drug whose prime purpose is to reverse the effects of the sedative dexmedetomidine (as well as its racemic mixture, medetomidine). [note 1] [9] [10] It can also be used to reverse the related sedative xylazine. [11]
In 2014, the chemistry department of Iran's Imam Hossein University "sought kilogram quantities of medetomidine — a sedative it has researched as an aerosolized incapacitant — from Chinese ...