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  2. Interleukin 11 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_11

    [8] [9] It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130.

  3. Interleukin 11 receptor alpha subunit - Wikipedia

    en.wikipedia.org/wiki/Interleukin_11_receptor...

    Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. [5] Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which ...

  4. Oprelvekin - Wikipedia

    en.wikipedia.org/wiki/Oprelvekin

    Oprelvekin is recombinant interleukin eleven (IL-11), [1] a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

  5. Interleukin-11 receptor - Wikipedia

    en.wikipedia.org/wiki/Interleukin-11_receptor

    The interleukin 11 receptor is a type I cytokine receptor, binding interleukin 11. It is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit.

  6. Type I cytokine receptor - Wikipedia

    en.wikipedia.org/wiki/Type_I_cytokine_receptor

    Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif in the extracellular portion adjacent to the cell membrane.

  7. IL3RA - Wikipedia

    en.wikipedia.org/wiki/IL3RA

    The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5).

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  9. ST2 cardiac biomarker - Wikipedia

    en.wikipedia.org/wiki/ST2_Cardiac_Biomarker

    The ST2 cardiac biomarker (also known as soluble interleukin 1 receptor-like 1) is a protein biomarker of cardiac stress encoded by the IL1RL1 gene. ST2 signals the presence and severity of adverse cardiac remodeling and tissue fibrosis , which occurs in response to myocardial infarction , acute coronary syndrome , or worsening heart failure .

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