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Metoclopramide is a medication used to treat nausea, vomiting, gastroparesis, and gastroesophageal reflux disease. [5] It is also used to treat migraine headaches. [6]Common side effects include feeling tired, diarrhea, akathisia, and tardive dyskinesia.
The role for these products is between just the use of simple analgesics (paracetamol or ibuprofen) and the triptan class of drugs; although the latter are not options during pregnancy. [7] In the elderly although triptans are generally avoided, so too are antiemetics such as metoclopramide due to higher risks of side effects.
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They may be used for severe cases of gastroenteritis, especially if the patient is dehydrated. [1] [2]
Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...
In the 1970s, John Fozard found that metoclopramide and cocaine were weak antagonists at the 5-HT 3 (5-HT-M) receptor. Fozard and Maurice Gittos later synthesized MDL 72222, the first potent and truly selective 5-HT 3 receptor antagonist. [35] [36] The antiemetic effects of metoclopramide were found to be partially because of its serotonin ...
When compared to other antiemetics, maropitant has similar or greater effectiveness to chlorpromazine and metoclopramide for centrally mediated vomiting induced by apomorphine or xylazine. [11] It works better than chlorpromazine and metoclopramide for vomiting peripherally induced induced with syrup of ipecac. [17]
Electrolyte solutions, while not true antidiarrheals, are used to replace lost fluids and salts in acute cases. Bulking agents like methylcellulose , guar gum or plant fibre ( bran , sterculia , isabgol , etc.) are used for diarrhoea in functional bowel disease and to control ileostomy output.
[6] [7] Children and those in the developing world are affected the most. [15] In 2011, there were about 1.7 billion cases, resulting in about 700,000 deaths of children under the age of five. [16] In the developing world, children less than two years of age frequently get six or more infections a year. [17]