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Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus, which fluconazole is not. It is also licensed for use in blastomycosis, sporotrichosis, histoplasmosis, and onychomycosis.
Some fungi (e.g. Candida krusei and fluconazole) exhibit intrinsic resistance to certain antifungal drugs or classes, whereas some species develop antifungal resistance to external pressures. Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals ...
Onychomycosis, also known as tinea unguium, [4] is a fungal infection of the nail. [2] Symptoms may include white or yellow nail discoloration, thickening of the nail, and separation of the nail from the nail bed . [ 2 ]
But the truth is that toenail fungus or onychomycosis, to use the medical term, is incredibly common and can happen to anyone. In fact, 1 in 10 people are affected , and for those over 70, this ...
Onychomycosis Benzoxaborole antifungal is for the treatment of onychomycosis of toenails. It is applied to the affected toenail once daily for 48 weeks. The major adverse effects associated with its use is the ingrowing of toenails and application site reactions including exfoliation, erythema, and dermatitis.
Both itraconazole and fluconazole inhibits the synthesis of ergosterol which is an important component of fungal cell membranes. Consequently, fluconazole use leads to changes in the permeability and function of the cell membrane. [7] Squalene epoxidase contributes to the formation of ergosterol.
If allowed to grow for too long, athlete's foot fungus may spread to infect the toenails, [19] feeding on the keratin in them, a condition called onychomycosis. [20] Because athlete's foot may itch, it may also elicit the scratch reflex, causing the host to scratch the infected area before they realize it. Scratching can further damage the skin ...
Onychomycosis (also known as "dermatophytic onychomycosis", or "tinea unguium" [2] is a fungal infection of the nail. [8] It is the most common disease of the nails and constitutes about half of all nail abnormalities. [9] This condition may affect toenails or fingernails, but toenail infections are particularly common. It occurs in about 10% ...
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