Search results
Results from the WOW.Com Content Network
Reelin's name comes from the abnormal reeling gait of reeler mice, [17] which were later found to have a deficiency of this brain protein and were homozygous for mutation of the RELN gene. The primary phenotype associated with loss of reelin function is a failure of neuronal positioning throughout the developing central nervous system (CNS).
DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis. It docks to the intracellular part of the Reelin very low density lipoprotein receptor ( VLDLR ) and apoE receptor type 2 ( ApoER2 ) and becomes tyrosine-phosphorylated following binding of Reelin to ...
The product of the reeler gene in mouse is reelin, a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. [1] F-spondin and mindin are a family of matrix-attached adhesion molecules that share structural similarities and overlapping domains of expression. Both F-spondin and mindin ...
Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with ...
The examples include: Double knockout of VLDLR and ApoER2 receptors; [5] Double knockout of Src and Fyn kinases. [6] Cre-loxP recombination mice model that lacks Crk and CrkL in most neurons. [7] Was used to show that Crk/CrkL lie downstream of DAB1] in the reelin signaling pathway. Scrambler mouse; Brain slices of wildtype and reeler mice
A backup of an Excel Spreadsheet Add-in (DLL) .xll: Adds custom functionality; written in C++/C, Fortran, etc. and compiled into a special dynamic-link library: Macro .xlm: A macro is created by the user or pre-installed with Excel. Template .xlt: A pre-formatted spreadsheet created by the user or by Microsoft Excel. Module .xlv
It was found later that the mutation causing these disorders was located in the RELN gene which codes for reelin, a glycoprotein secreted by Cajal–Retzius cells in the developing brain. This protein seems to act as a stop signal for migrating neurons, controlling the positioning and orientation of neurons in their layers, according to the ...
Both free and paid versions are available. It can handle Microsoft Excel .xls and .xlsx files, and also produce other file formats such as .et, .txt, .csv, .pdf, and .dbf. It supports multiple tabs, VBA macro and PDF converting. [10] Lotus SmartSuite Lotus 123 – for MS Windows. In its MS-DOS (character cell) version, widely considered to be ...