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Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for ...
Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA. [20] DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS). [54] [55] The terminal half-life of DHEA is short at only 15 to 30 minutes. [56] In contrast, the terminal half-life of DHEA-S is far longer, at 7 to 10 hours. [56]
DHEA can be lower in people with depression and after menopause, and levels tend to decrease as you age. At age 70 to 80, DHEA levels may be down to 10 to 20 percent of those in a younger person ...
Prasterone enanthate, also known as dehydroepiandrosterone enanthate (DHEA-E) and sold in combination with estradiol valerate under the brand name Gynodian Depot among others, is a weak androgen, estrogen, and neurosteroid medication which is used as a component of menopausal hormone therapy to treat menopausal symptoms in women.
The Australian Menopause Society has similarly stated that there is no evidence that bioidentical hormones administered using lozenges are any safer than their approved counterparts. [53] [54] The International Menopause Society has stated "There are no medical or scientific reasons to recommend unregistered 'bioidentical hormones'. The ...
Treatment: A couple of options for treating menopause-related dryness are prescription local vaginal estrogen pills, creams, or rings. There are also non-hormonal options such as DHEA and the CO2 ...
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