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Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [ 10 ] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999.
On July 14, 2022, YouTube made a special playlist and video celebrating the 317 music videos to have hit 1 billion views and joined the "Billion Views Club". [ 65 ] [ 66 ] On April 1, 2024, the communications app Discord incorporated a short trailer video into their in-app April Fools' Day prank regarding loot boxes .
Flurazepam [2] (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
In 2015, the American Geriatrics Society reviewed the safety information about eszopiclone and similar drugs and concluded that the "nonbenzodiazepine, benzodiazepine receptor agonist hypnotics (eszopiclone, zaleplon, zolpidem) are to be avoided without consideration of duration of use because of their association with harms balanced with their ...
[75] [76] In response, YouTube co-founder Jawed Karim posted the question "why the fuck do I need a google+ account to comment on a video?" on his YouTube channel to express his negative opinion of the change. [77] The official YouTube announcement [78] received 20,097 "thumbs down" votes and generated more than 32,000 comments in two days. [79]
Triazolam is usually used for short-term treatment of acute insomnia and circadian rhythm sleep disorders, including jet lag.It is an ideal benzodiazepine for this use because of its fast onset of action and short half-life.
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For treatment of insomnia, benzodiazepines are now less popular than nonbenzodiazepines, which include zolpidem, zaleplon and eszopiclone. [212] Nonbenzodiazepines are molecularly distinct, but nonetheless, they work on the same benzodiazepine receptors and produce similar sedative effects. [213]