Search results
Results from the WOW.Com Content Network
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. [6] PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
PKC-zeta has an N-terminal regulatory domain, followed by a hinge region and a C-terminal catalytic domain. Second messengers stimulate PKCs by binding to the regulatory domain, translocating the enzyme from cytosol to membrane, and producing a conformational change that removes auto-inhibition of the PKC catalytic protein kinase activity.
18750 Ensembl ENSG00000154229 ENSMUSG00000050965 UniProt P17252 P20444 RefSeq (mRNA) NM_002737 NM_011101 RefSeq (protein) NP_002728 NP_035231 Location (UCSC) Chr 17: 66.3 – 66.81 Mb Chr 11: 107.82 – 108.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Function Protein kinase C (PKC) is a ...
18752 Ensembl ENSG00000126583 ENSMUSG00000078816 UniProt P05129 P63318 RefSeq (mRNA) NM_002739 NM_001316329 NM_001291434 NM_011102 RefSeq (protein) NP_001303258 NP_002730 NP_001278363 NP_035232 Location (UCSC) Chr 19: 53.88 – 53.91 Mb Chr 7: 3.34 – 3.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG ...
Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene. [5] PKC-θ, a member of serine/threonine kinases, is mainly expressed in hematopoietic cells [ 5 ] with high levels in platelets and T lymphocytes , where plays a role in signal transduction.
Human PRKCE gene (Ensembl ID: ENSG00000171132) encodes the protein PKCε (Uniprot ID: Q02156), which is 737 amino acids in length with a molecular weight of 83.7 kDa. The PKC family of serine-threonine kinases contains thirteen PKC isoforms, and each isoform can be distinguished by differences in primary structure, gene expression, subcellular localization, and modes of activation. [7]
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.