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Cholinergic urticaria may significantly impair quality of life, especially in relation to normal day to day activities. It is caused by an overreaction of the immune system to the release of histamine, mast cells, and other chemicals in response to the small nerve fibers throughout the body due to the increase in body temperature being allergic ...
Cholinergic urticaria (CU) is one of the physical urticaria (hives) which is provoked during sweating events such as exercise, bathing, staying in a heated environment, or emotional stress. The hives produced are typically smaller than classic hives and are generally shorter-lasting.
Hives, also known as urticaria, is a kind of skin rash with red and/or flesh-colored, raised, itchy bumps. [1] Hives may burn or sting. [2] The patches of rash may appear on different body parts, [2] with variable duration from minutes to days, and do not leave any long-lasting skin change. [2]
The first outbreak of urticaria can lead to other reactions on body parts not directly stimulated, scraped, or scratched. In a normal case, the swelling will decrease without treatment within 15–30 minutes, but, in extreme cases, itchy red welts may last anywhere from a few hours to days.
[9] [10] Treatment primarily involves managing symptoms and includes the use of antihistamines, corticosteroids, monoclonal antibodies , and in some cases, immunosuppressive drugs. [11] [12] Despite ongoing research, many aspects of autoimmune urticaria remain poorly understood, and it continues to be a challenging condition to manage.
As a result, heat builds up during physical activity or in hot conditions. Such individuals may exhibit a variety of symptoms, including facial flushing, headaches, disorientation, lassitude, hyperthermia, weakness, and palpitations. Certain patients may get heatstroke. In addition, cholinergic urticaria's prickling pain and rash are commonly ...
Acetaldehyde is also linked to some of the unpleasant symptoms of alcohol intoxication, such as headaches, flushing, hives and nausea, according to Lee. This type of genetic test may provide an ...
Cholinergic urticaria or sharp pain over the entire body induced by elevated body temperature was reported in 32 cases (50%). Of 28 cases tested, 12 (43%) displayed elevated serum IgE levels. Skin biopsy was performed in 53 cases, with normal findings in 20 cases (38%), and cellular infiltrates in sweat glands or ducts in 23 cases (43%).
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