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An antral or secondary follicle, also known as Graafian follicle and tertiary follicle, is an ovarian follicle during a certain latter stage of folliculogenesis. Definitions differ in where the shift into an antral follicle occurs in the staging of folliculogenesis, with some stating that it occurs when entering the secondary stage, [ 1 ] and ...
In addition, follicles that have formed an antrum are called antral follicles or Graafian follicles. Definitions differ in where this shift occurs in the staging given above, with some stating that it occurs when entering the secondary stage, [ 2 ] and others stating that it occurs when entering the tertiary stage.
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle . At the time of puberty , women have approximately 200,000 to 300,000 follicles, [ 1 ] [ 2 ] each with the potential to release an egg cell (ovum) at ovulation for fertilization . [ 3 ]
Follicular phase diagram of hormones and their origins Follicle-stimulating hormone (FSH) is secreted by the anterior pituitary gland (Figure 2). FSH secretion begins to rise in the last few days of the previous menstrual cycle, [ 3 ] and is the highest and most important during the first week of the follicular phase [ 4 ] (Figure 1).
CCs primarily support growth and development of the oocyte whereas MGCs primarily serve an endocrine function and support the growth of the follicle. Cumulus cells aid in oocyte development and show higher expression of SLC38A3, a transporter for amino acids, and Aldoa, Eno1, Ldh1, Pfkp, Pkm2, and Tpi1, enzymes responsible for glycolysis. [ 7 ]
The labels in the folliculogenesis diagram (Folliclesinovary.jpg) are incorrect - they have been reversed. The arrow is pointing in the wrong direction "Corpus albicans" should be "Primary follicle" "Mature corpus luteum" should be "Secondary follicle" "Corpus luteum" should be "Graafian follicle" or "Mature vesicular follicle" etc.
Stigma of the human ovary: the follicle is about to burst. A stigma, also called macula pellucida, in mammalian reproductive anatomy, refers to the area of the ovarian surface where the Graafian follicle will burst through during ovulation and release the ovum. [1]
In the antral follicle, there is an antrum containing a follicle liquor, which contains estrogen, to allow the passage from the antral follicle to the Graaf follicle. The follicular antrum moves the oocyte and becomes eccentric; the oocyte is always surrounded by the pellucid zone and by follicular cells that form the oophorus cumulus.