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The term functional genomics is often used to refer to the many technical approaches to study an organism's genes and proteins, including the "biochemical, cellular, and/or physiological properties of each and every gene product" [2] while some authors include the study of nongenic elements in their definition. [3]
Convergent Functional Genomics (CFG) Developed by Alexander Niculescu, MD, PhD, and collaborators starting in 1999, [1] it is an approach for identifying and ...
Functional genomics attempts to answer questions about the function of DNA at the levels of genes, RNA transcripts, and protein products. A key characteristic of functional genomics studies is their genome-wide approach to these questions, generally involving high-throughput methods rather than a more traditional "gene-by-gene" approach.
Cognitive genomics: Study of the changes in cognitive processes associated with genetic profiles. Comparative genomics: Study of the relationship of genome structure and function across different biological species or strains. Functional genomics: Describes gene and protein functions and interactions (often uses transcriptomics).
Comparative genomics approaches were used to predict the function-relevant variants under the assumption that the functional genetic locus should be conserved across different species at an extensive phylogenetic distance. On the other hand, some adaptive traits and the population differences are driven by positive selections of advantageous ...
The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between ...
The Encyclopedia of DNA Elements (ENCODE) is a public research project which aims "to build a comprehensive parts list of functional elements in the human genome." [2]ENCODE also supports further biomedical research by "generating community resources of genomics data, software, tools and methods for genomics data analysis, and products resulting from data analyses and interpretations."
This systematic approach to studying epistasis on a genome wide scale has significant implications for functional genomics. By identifying the negative and positive interactions between an unknown gene and a set genes within a known pathway, these methods can elucidate the function of previously uncharacterized genes within the context of a ...
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