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This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Bebtelovimab is a neutralizing human immunoglobulin G1 (IgG1) monoclonal antibody, isolated from a patient who has recovered from the Coronavirus disease 2019 (COVID-19), directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19.
Bamlanivimab is a monoclonal antibody developed by AbCellera Biologics and Eli Lilly as a treatment for COVID-19. [8] The medication was granted an emergency use authorization (EUA) by the US Food and Drug Administration (FDA) in November 2020, [9] [10] [11] and the EUA was revoked in April 2021.
Monoclonal antibodies are no longer available to treat Covid in the U.S. after the FDA rescinded its authorization of the last one standing, bebtelovimab.
A benefit of casirivimab and imdevimab treatment has not been shown in people hospitalized due to COVID‑19. [9] Monoclonal antibodies, such as casirivimab and imdevimab, may be associated with worse clinical outcomes when administered to hospitalized people with COVID‑19 requiring high flow oxygen or mechanical ventilation. [9]
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Monoclonal antibodies under investigation for repurposing include anti-IL-6 agents (tocilizumab) [17] and anti-IL-8 (BMS-986253). [18] (This is in parallel to novel monoclonal antibody drugs developed specifically for COVID-19.) Mavrilimumab is a human monoclonal antibody that inhibits human granulocyte macrophage colony-stimulating factor ...
The U.S. Food & Drug Administration granted emergency-use authorization last year. Some hospitals don't offer monoclonal antibodies to fight COVID-19.
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