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The medications ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) have been used in treatment to dissolve gallstones. [58] [59] A 2013 meta-analysis concluded that UDCA or higher dietary fat content appeared to prevent formation of gallstones during weight loss. [41]
Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria.It is synthesized in the liver in some species, and was first identified in bile of bears of genus Ursus, from which its name derived. [8]
[7] [8] Medical therapy with oral bile acids has been used in patients who have small cholesterol stones, and for patients with larger cholesterol gallstones who are unable or reluctant to have surgery. CDCA treatment can cause diarrhea, mild reversible hepatic injury, and a small increase in the plasma cholesterol level. [8]
Monoctanoin (or monocaprylin; trade name Moctanin) is a monoglyceride used to dissolve gallstones consisting of cholesterol. It is not available in the US any more. [1] The drug was given by injection through a catheter into the bile duct. Its most common adverse effects were abdominal or stomach pain, usually mild, or a burning sensation. [1]
Lower concentrations of bile acids or phospholipids in bile reduce cholesterol solubility and lead to microcrystal formation. Oral therapy with chenodeoxycholic acid and/or ursodeoxycholic acid has been used to dissolve cholesterol gallstones. [27] [28] [29] Stones may recur when treatment is stopped.
The following over-the-counter medications can help relieve a stomachache, according to Singhal and Beery: Gas-X or simethicone-containing products dissolve excessive gas in the stomach and ...
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